PHARMACODYNAMICS OF A RADIOPROTECTIVE DRUG: 2-(1-DECYLAMINO) ETHANETHIOSULFURIC ACID

Abstract

One phase of the search for radioprotective agents is the study of the physiologic and pharmacologic mechanisms responsible for toxic and protective effects. In this study, the drug 2-(1-decylamino)ethanethiosulfuric acid (WR-1607) was injected, according to different dosage schedules, into control and irradiated Macaca mulatta monkeys. Changes in hemograms and blood chemistries were measured, and clinical observations were recorded. The response in control animals appeared to be that to a temporary chemical challenge with prompt recovery within one week. In the irradiated animals, the response corresponded to a subacute radiation syndrome. In this experiment, WR- 1607 failed to mobilize physiologic mechanisms for protection against radiation injury. Further investigation of this drug as a radioprotectant should consider a different approach in method of administration.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1969
Accession Number
AD0692983

Entities

People

  • George S. Melville Jr.
  • Jose A. Martinez-o'ferrall

Organizations

  • United States Air Force School of Aerospace Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Aerospace Medicine
  • Air Force
  • Air Force Facilities
  • Animals
  • Bilirubin
  • Blood
  • Blood Chemistry
  • Body Weight
  • Chemistry
  • Ionizing Radiation
  • Leukocytes
  • Lymphocytes
  • Radiation
  • Radiation Injuries
  • Radiation Sickness
  • Radioprotective Agents

Fields of Study

  • Biology
  • Medicine

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Nuclear and Radiation Engineering.
  • Virology (or Medical Virology).