FUNCTION OF SIALIDASE IN INFLUENZA VIRUSES.
Abstract
In order to investigate the function of sialidase during influenza virus multiplication, methods were developed to isolate and purify the enzyme. With purified enzyme it was possible to characterize the enzyme and to determine the role of the enzyme. Among the properties studied the antigenicity of sialidases from myxoviruses best characterized the enzyme. This was accomplished by preparing highly specific enzyme antisera. The specific enzyme antiserum provided us with the critical reagent by which we demonstrated that the function of the enzyme facilitates the release of virus from infected cells. This was shown by in vitro biological assays and morphological examination by electron microscopy. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1969
- Accession Number
- AD0693214
Entities
People
- Joseph T. Seto
Organizations
- California State University, Los Angeles