CARDIORESPIRATORY AND METABOLIC RESPONSES TO LIVE E. COLI AND ENDOTOXIN IN THE MONKEY
Abstract
Septicemia and the administration of endotoxin may have different effects in the production of shock. Hemodynamic, respiratory, and metabolic effects of live organisms (Escherichia coli) were compared with endotoxin and saline in rhesus monkeys. Six animals were given E. coli, six endotoxin, and five served as controls. Studies were conducted for 2-4 hours. The mean cardiac output decreased 62% within 60-90 minutes in the E. coli group and 41% in the endotoxin group. This was associated with a dramatic decrease in systemic pressure and peripheral resistance in all animals. The mean arterial Pco2 decreased to 24 mm Hg in the E. coli group and 26 mm Hg in the endotoxin group. Arterial hypoxemia developed in four animals and high alveoloarterial oxygen gradients were present at some time during the study in all the animals. Blood lactate levels increased and catecholamine levels arose after 1-2 hours of hypotension. Control animals did not demonstrate these changes. The profound hemodynamic, respiratory, and metabolic effects of the septicemia in the monkey simulate observations in humans in septic shock. The rate of onset of measurable changes and the severity of hypoxia were the major differences observed in E. coli and endotoxin groups.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 11, 1969
- Accession Number
- AD0693625
Entities
People
- C. A. Guenter
- L. B. Hinshaw
- V. Fiorica
Organizations
- University of Oklahoma