ATTRACTIVENESS AND REPELLENCY OF MAN TO MOSQUITO BITES.
Abstract
The attractiveness of various fractions of human body emanations and sweat to the female A. aegypti mosquito was investigated. A simplified dual-port olfactometer has been used for these studies and those on synthetic and natural repellents from skin-surface lipids. Components from skin-surface lipids that were repellent to mosquitoes have been isolated via a sequence of molecular distillation, high-vacuum fractionation, thin-layer silica gel chromatographic (TLC) separation and gas-liquid chromatographic (GLC) separation. A series of butane sulfonamides related to a Russian mosquito repellent were synthesized. The attractive components in human sweat have been separated in semipure form by the following sequence: lyophilization, molecular distillation, gas chromatographic separation, and condensation of individual peaks. A method of ascertaining intrinsic repellency of chemicals has been developed and a survey of the intrinsic repellency of a series of chemicals possessing similar boiling points has been conducted. A series of acid-labile compounds has been synthesized and evaluated on human skin for duration of repellency. Arm vapors have been found to be attractive to A. aegypti when passed into a large cage olfactometer. The attractive factor(s) present in these arm vapors can be removed by the use of an ice bath. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1969
- Accession Number
- AD0693891
Entities
People
- W. A. Skinner
Organizations
- SRI International