MONKEYS AS HOSTS OF HUMAN MALARIA.
Abstract
The object of this work is to determine if human malaria can be grown in monkeys and to determine the feasibility of such a model for the detailed study of this important human disease. Previously we have reported that five species of Panamanian monkeys were susceptible to Plasmodium vivax of human origin and that Panama P. falciparum would grow only poorly in one monkey. During the past year, additional strains of P. vivax have been adapted to these monkey hosts, and it was shown that serial passages of this malaria through unaltered (normal) monkeys was practical. Cebus capucinus and Saimiri sciureus monkeys were shown to be susceptible to P. falciparum of foreign origin. The parasites grew much better in the Cebus. Successful mosquito passages of P. vivax were made from monkey to monkey. Significantly, some of these were to unaltered (normal) monkeys. Two species of potential mosquito vectors were established in colony, viz., Anopheles pseudopunctipennis for 14 months and A. triannulatus for a shorter period. In contrast to the Panama parasites, P. falciparum of foreign origin grew well in the Panama Aotus monkey. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1969
- Accession Number
- AD0694474
Entities
People
- David C. Baerg
- Martin D. Young
- Richard N. Rossan