THE MECHANISM OF HISTAMINE-INDUCED TRAMSCAPILLARY FLUID MOVEMENT.
Abstract
The study was designed to determine the direct effect of histamine on capillary membrane permeability and pre- and post-capillary resistances. Ten experiments were carried out on isolated forelimbs of dogs perfused with blood oxygenated by a Starling heart-lung preparation. Permeability was determined by measuring the isogravimetric capillary pressure (Pci) using a modification of the Pappenheimer and Soto-Rivera technique. It is suggested that histamine increases the permeability of the capillaries due to a direct action on the capillary membrane. Additional increases in hydrostatic capillary pressure may contribute to net capillary filtration induced by histamine. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 11, 1969
- Accession Number
- AD0695006
Entities
People
- L. B. Hinshaw
- W. Dietzel
- W. H. Massion
Organizations
- University of Oklahoma