THE EFFECT OF X IRRADIATION ON DELAYED HYPERSENSITIVITY AND CIRCULATING ANTIBODY

Abstract

Rats exposed to x radiation 24 hours prior to antigen administration exhibited detectable skin reactions to tuberculin 2 days later than nonirradiated sensitized controls. Reaction sizes illustrate that the irradiated rat experienced a decreased sensitivity to tuberculin which persisted through day 14. The radiation dose (475 rads) responsible for the observed depression of the delayed skin reactions produced a greater depression of the circulating antibody response. The results obtained suggest that the cellular and humoral immune responses in the rat are radiosensitive.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1969
Accession Number
AD0695424

Entities

People

  • D. B. Spence
  • E. D. Exum
  • R. T. Bowser

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Antibodies
  • Blood
  • Blood Proteins
  • Cells
  • Contrast
  • Depression
  • Lagomorphs
  • Proteins
  • Radiation
  • Reactivities
  • Rodents
  • Sensitivity
  • Skin Tests
  • Veins
  • X Rays

Fields of Study

  • Biology

Readers

  • Nuclear and Radiation Engineering.
  • Organic Chemistry
  • Toxicology/Environmental Toxicology