ACRIDINE DYES AS EFFICIENT REGULATORS OF PHOTOCHEMICAL REACTIONS IN NUCLEIC ACIDS

Abstract

In the present work a comparative study is made of the protective action of a number of acridine dyes during UV-irradiation both of double-helical and the single-strand forms of DNA. Conditions are determined for exposing the protective effect and equilibrium constants are calculated for the process of complex-formation of dye with DNA with the manifestation of a protective effect. It is shown that at the maximum binding the dye atabrine inhibits 96% of lethal photoreactions in DNA.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 02, 1969
Accession Number
AD0695572

Entities

People

  • G. B. Zavilgelskii
  • O. N. Rudchenko
  • V. V. Danileichenko

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Acids
  • Acridines
  • Albumins
  • Bacteriophages
  • Chemical Synthesis
  • Chemistry
  • Coliphages
  • Macromolecules
  • Microbiology
  • Migration
  • Molecular Biology
  • Molecules
  • Nitrogen
  • Nucleic Acids
  • Photochemical Reactions
  • Pyrimidines
  • Quantum Yields

Fields of Study

  • Chemistry
  • Physics

Readers

  • Molecular Genetics
  • Molecular Photonics/Laser Physics
  • Parasitology and Pharmacology of Malaria.

Technology Areas

  • Biotechnology