INDUCTION OF r- AND hc-MUTATIONS DURING THE TREATMENT OF EXTRACELLULAR T-2 BACTERIOPHAGE WITH HYDROXYLAMINE AND O-METHYL-HYDROXYLAMINE
Abstract
An analysis of the induction of r- and h-mutations during treatment of extracellular T-2 bacteriophage with hydroxylamine and O-methylhydroxylamine made it possible to reveal the diverse mutagenic activity of these compounds. The lower induction of mutations during treatment of phage with O- methylhydroxylamine is probably connected either with the lesser rate of change of hydroxymethylcytosine in the DNA of T-2 phage or with the diverse complementary activity of the derivatives of hydroxymethylcytosine which are formed in both cases. The diverse rate of induction of r- and h-mutations during treatment of T-2 phage with hydroxylamine and O-methylhydroxylamine may be explained both by the various extent and by the heterogeneity on pairs of nitrogen bases of genetic segments which control the stated properties.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 29, 1969
- Accession Number
- AD0695595
Entities
People
- S. G. Tatarinova
- V. F. Chubukov
Organizations
- United States Army Biological Warfare Laboratories