ANTIGENICITY OF PSITTACOSIS VACCINES KILLED BY IONIZING RADIATION (33994)

Abstract

Exposure of suspensions of the Borg strain of Chlamydia psittaci to graded doses of gamma radiation resulted in loss of infectivity. Exposure in the frozen state produced slower loss of infectivity than exposure in the fluid state, doses of 400,000 and 250,000 R being required, respectively, for complete loss of detectable infectivity. Both reactions deviated moderately from first- order behavior. The frozen suspensions retained greater antigenicity for mice than did the fluid suspensions and were also more antigenic than suspensions killed by treatment with formaldehyde.

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Document Details

Document Type
Technical Report
Publication Date
Feb 28, 1969
Accession Number
AD0696013

Entities

People

  • George G. Wright
  • John R. Mitzel
  • Norman S. Swack

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biology
  • Cells
  • Chlamydophila
  • Culture Techniques
  • Data Science
  • Diploid Cells
  • Dose Rate
  • Factor Analysis
  • Formaldehyde
  • Gamma Rays
  • Gram-Negative Bacterial Infections
  • Health Services
  • Ionizing Radiation
  • Materials
  • Radiation
  • Statistical Analysis
  • Tissue Culture

Readers

  • Immunology
  • Nuclear and Radiation Engineering.
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology