THE ROLE OF INHIBITION IN INFORMATION TRANSFER. PART 2. THE INTERACTION OF CENTRIFUGAL AND CENTRIPETAL STIMULATION ON NEURONES OF THE COCHLEAR NUCLEUS.
Abstract
The micro-tap technique has been used to apply pharmacologically active substances to neurones of the cochlear nucleus. Neither strychnine nor picrotoxin had any influence on centripetally induced inhibition, so that no light is thrown on the question of whether such inhibition might be pre- or post-synaptic. Acetylcholine has been shown to have a uniformly excitatory, and noradrenaline an inhibitory action on cells of the cat cochlear nucleus. Evidence is presented that the centrifugal pathway from the lateral superior olive to the cochlear nucleus may be cholinergic. Electrical stimulation of this pathway lowers the threshold of ventral cochlear nucleus neurones to sound stimuli. Electrical stimulation of the nuclei of the lateral lemniscus produces predominantly inhibition of individual neurones of the contralateral cochlear nucleus, though in some circumstances excitation is seen. The nature of the centrifugal cochlear mechanism is discussed. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 30, 1966
- Accession Number
- AD0696174
Entities
People
- I. C. Whitfield
- S. D. Comis
Organizations
- University of Birmingham