A STUDY OF THE METABOLIC ASPECTS OF THERAPY OF RADIATION INJURY IN THE SOLDIER
Abstract
The report is the third in a series of three reviews of promising research opportunities to improve the treatment of ionizing radiation injury in the soldier. It complements the first report on A Study of the Immunologic Aspects of Therapy of Radiation Injury in the Soldier, AD-674 262, and A Study of Early Radiation-Induced Biological Changes as Indicators of Radiation Injury, AD-685 840. Early symptoms produced by radiation exposure are related to the abnormal physiology and cellular lesions of the gastrointestinal tract. These symptoms have diagnostic value but the pathologic changes are not readily amenable to medical treatment. This report reviews recent research on the effects of radiation on the gastrointestinal tract of man and experimental animals including: gastrointestinal symptomatology; immediate post-irradiation cellular events; morphologic responses; gastrointestinal and hematopoietic correlations; intestinal motility and malabsorption; intestinal flora changes; antibiotics in radiation therapy; radiation-induced vomiting; transport of fluid, electrolytes, nutrients, and other essential elements; and alterations in drug metabolism. In reviewing these aspects of the radiation-induced 'gastrointestinal syndrome' therapeutic opportunities are identified. Suggested areas for future research emphasis are summarized. A critical literature review entitled The Gastrointestinal Syndrome in Acute Radiation Injury and an annotated evaluative bibliography constitute Part II of the report.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1969
- Accession Number
- AD0696445
Entities
Organizations
- Federation of American Societies for Experimental Biology