STUDIES ON TICK-BORNE ENCEPHALITIS AND OTHER ARTHROPOD-BORNE VIRUS DISEASES
Abstract
Three new foci of TBE virus were located in Upper Austria. Shrews are not essential for virus cycle in Lower Austria. Survey with sera of game showed that TBE foci are scarcer in the West than in the East of Lower Austria. HI test was as specific but less sensitive than the NT. Receptor-analogue substances for TBE virus are probably Ca- and Mg-salts of polyphosphoinositides. Different strains of TBE virus induced the same level of interferon in babymouse brain. Other viruses of the TBE complex gave slightly higher interferon titers. The interferon inducing compound Poly I:C exhibited excellent protection against infection with TBE virus in mice. Experimental studies showed that foxes, polecats and weasels can act as host of TBE virus. The main arthropod and vertebrate hosts of Tahyna and Calovo viruses were established. Neither heterothermal nor poikilothermal vertebrates can maintain the virus cycle in winter. Overwintering of Calovo virus in Anopheles maculipennis is conceivable. 'Marburg virus' replicated in Aedes aegypti but failed to multiply in Anopheles maculipennis and in Ixodes ricinus. The virus did not induce fermation of interferon in brains of baby mice and was not inhibited by Poly I:C. The agent produces CPE in ELF cells. CF test was found to be useful for diagnosis of 'Marburg virus' disease. Animals from Anatolia had antibodies against arboviruses of groups A and B.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1969
- Accession Number
- AD0696524
Entities
People
- A. Radda
- Ch. Kunz
- H. Aspoeck
- Heath Hofmann
- W. Frisch
Organizations
- University of Vienna