CHROMIUM COMPLEXES OF INSULIN AND RELATED COMPOUNDS.
Abstract
The method of sequential dialysis has been developed by which biological compounds can be efficiently evaluated in this respect. The method has been used extensively in studying the reactions of Cr(III), which is essential to the functioning of insulin, with many biological ligands including amino acids, bases, biological phosphates, most of the compounds of the Krebs cycle and many of the glycolytic chain. The most effective form compounds with Cr(III) having constant rates of transport through membranes for several days. Among these are citrate, isocitrate, mesoxalate, tartronate, ADP, ATP, thiamine pyrophosphate, histidine, fructose-1,6-diphosphate and 3-phosphoglycerate. Work in progress includes extension of these studies to additional biological ligands, different concentrations of reactants and essential metal ions other than Cr(III). (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1969
- Accession Number
- AD0698478
Entities
People
- Carl L. Rollinson
- Eleanor W. Rosenbloom
Organizations
- University of Maryland