CHANGES IN THE REFLEX TIME, SPONTANEOUS MOTOR ACTIVITY, PHYSICAL ENDURANCE AND EFFICIENCY OF ANIMALS UNDER THE INFLUENCE OF RADIOPROTECTIVE AGENTS,
Abstract
Cystamine and N,N'-tetramethylcystamine (TMC) in doses of 25 and 50 mg/kg induce suppression of the reflex function of the spinal cord. N,N'-difurfurylcystamine (DFC) induces a moderate lengthening of the time of the latent period of the flexion reflex in rabbits but only in a dose of 50 mg/kg. Rapid intravenous injection of rabbits with large doses of cystamine and TMC causes toxic phenomena which are not observed when the preparations are injected slowly. Cystamine, TMC and DFC in doses of 10, 50, 100 and 150 mg/kg depress the motor activity and physical endurance of white mice. Moreover, as dosages of the preparations are increased, the effect of their action increases. Cystamine and DFC in doses of 10, 50 and 100 mg/kg reduce the static efficiency of white mice. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 12, 1970
- Accession Number
- AD0698885
Entities
People
- A. P. Bodakva