SECONDARY EVALUATION OF ANTIMALARIAL AGENTS

Abstract

The objective of this research program is to screen potential antimalarial agents against Plasmodium berghei infections in mice. In addition to the use of blood induced normal and drug resistant infections, procedures were established for the use of sporozite induced infections of P. berghei yoelii in testing for casual prolactic as well as blood schizontocidal activity. Special studies were also made to differentiate the action of drugs that apparently exhibit both types of activity as well as to determine the period of infectivity of various tissues following sporozoite infection.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1970
Accession Number
AD0699833

Entities

People

  • Alan M. Shefner
  • Maurice E. King

Organizations

  • IIT Research Institute

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Antimalarials
  • Cells
  • Chemical Reactions
  • Infection
  • Intervals
  • Laboratory Animals
  • Magnetic Tape
  • Malaria
  • Materials
  • Parasitic Diseases
  • Plastic Explosives
  • Primaquine
  • Test And Evaluation
  • Test Methods
  • Time Intervals
  • Wound Infections

Fields of Study

  • Medicine

Readers

  • Parasitology and Pharmacology of Malaria.