MINIATURE PIG PERFORMANCE AFTER FRACTIONATED DOSES OF IONIZING RADIATION
Abstract
Miniature pigs were trained to traverse on cue a two-chambered shuttlebox. The pigs received either unfractionated (6500, 8600, 11,600, or 13, 000 rads) or fractionated (6800, 8500, 11,000, or 13,300 rads) doses of pulsed mixed gamma-neutron radiation. The fractionated doses were delivered as two equal fractions 5 hours apart. Miniature pig performance after the second half of the fractionated dose was similar to or better than the performance observed after the first half of the dose. The pig's performance was markedly better when the dose was fractionated than when it was unfractionated; early transient incapacitation was shorter, and acceptable performance was achieved earlier and lasted longer. Also, mean survival times of the pigs that received fractionated doses were longer. Possible mechanisms which may be responsible for the reduced effectiveness of the fractionated doses are discussed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1969
- Accession Number
- AD0700237
Entities
People
- R. L. Chaput
- R. T. Kovacic
Organizations
- Armed Forces Radiobiology Research Institute