DETECTION OF BIOLOGIC CHANGES IN ANIMALS EXPOSED TO LOW LEVELS OF IONIZING RADIATION.
Abstract
Urinary excretion of fluorescent products was investigated in Macaca mulatta exposed to whole-body, single dose cobalt-60 gamma irradiation of 28, 53, and 106 rads. Ion-exchange and gel-filtration chromatography were used to fractionate and quantitate radiation-responsive urinary products. Radiation dose response relationships were measurable in one major fluorescent fraction within 72 hours postirradiation at all dose levels. A radiation response relationship was measurable within 6 hours at the 106-rad level. The radiation responsive fluorescent subfraction appears to be predominantly composed of large molecular weight (700 to 1,500) acidic heterocyclic amines. The major source of deviation from linearity of response to dose arose from the large variation in the volume of urine excreted by the monkeys. Much greater and earlier correlation between the low irradiation doses and the level of excretory products could probably be obtained by controlling the water intake of the animals. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1969
- Accession Number
- AD0700724
Entities
People
- Frank M. Maciasr
- Jack M. Beattie