ATTEMPT TO CLONE MARROW CELLS IN SPLEENS OF LETHALLY IRRADIATED RHESUS MONKEYS

Abstract

An attempt was made to clone rhesus marrow cells within the spleens of lethally irradiated rhesus monkeys. Twelve animals received autologous transplants; 2 animals received allogeneic transplants; and 4 animals served as irradiation controls. Ten days following transplantation (or irradiation, in the case of the controls) the animals were sacrificed and their spleens removed. No macroscopic nodules were found in any of the spleens; microscopic examination of subserial sections revealed scattered erythrocytic clones in 3 of 14 animals that received transplants. Reticulocyte counts, peripheral leukocytes, and cellularity of marrow spaces indicated that the transplanted marrow had proliferated in 13 of the 14 animals with transplants. Under our conditions, significant marrow cloning did not occur in spleens of lethally irradiated rhesus monkeys in a manner analogous to that described in similar studies with rodents.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1969
Accession Number
AD0700742

Entities

People

  • Harold W. Casey
  • James R. Eltringham

Organizations

  • United States Air Force School of Aerospace Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Aerospace Medicine
  • Air Force
  • Air Force Facilities
  • Animals
  • Blood
  • Bone Marrow
  • Bone Marrow Cells
  • Bones
  • Cells
  • Erythrocytes
  • Government Procurement
  • Governments
  • Laboratory Animals
  • Leukocytes
  • Lymphatic System
  • Lymphocytes
  • Rhesus Monkeys

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology
  • Neuroscience
  • Nuclear and Radiation Engineering.

Technology Areas

  • Biotechnology
  • Space