EVALUATION OF STROMA FREE HEMOGLOBIN SOLUTION: EFFECTS ON RENAL FUNCTION IN CYNOMOLGUS MONKEYS.

Abstract

Infusion of stroma free hemoglobin solution into cynomolgus monkeys produced no adverse effects on renal function or architecture even with prior stress in the form of dehydration, phlebotomy, or both. A transient fall in CPAH was noted in some animals. Urinary hemoglobin excretion was large in animals (30% of injected dose in 4 hr) and urinary concentration reached 10 to 20 g/100 ml when urine flow was low because of dehydration. The rapid urinary hemoglobin excretion in part accounts for the short plasma half disappearance time of about 120 min. No severe activation of blood coagulation was documented. These observations suggest stroma free hemoglobin should have further consideration as a resuscitation fluid. (Author)

Document Details

Document Type
Technical Report
Publication Date
Nov 20, 1969
Accession Number
AD0701886

Entities

People

  • Harry Lopas
  • Norman I. Birndorf

Organizations

  • United States Army Medical Research Laboratory

Tags

DTIC Thesaurus Topics

  • Blood Chemistry
  • Blood Coagulation
  • Blood Physiological Phenomena
  • Blood Physiological Processes
  • Circulatory And Respiratory Physiological Phenomena
  • Dehydration
  • Excretion
  • Hematology
  • Hemoglobin
  • Hemostasis
  • Infusions
  • Internal Medicine
  • Medical Specialties
  • Observation
  • Resuscitation

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology