THE PULMONARY RESPONSE TO HEMORRHAGIC SHOCK
Abstract
Indicator dilution methodology has been applied to the study of pulmonary hemodynamics and ventilatory function before and after hemorrhagic shock and in in-vitro perfused lungs. New sampling techniques have been developed and new mathematical models applied to data analysis. Both vascular distention and the recruitment of new flow channels may play important roles in adaptive changes of the normal lung to varying cardiac outputs. After shock, pulmonary edema or prolonged in-vitro perfusion, pulmonary artery pressure rises and there is derecruitment. Other factors found to be of significance in the distribution of pulmonary flow and pulmonary function include posture, oxygen breathing and the pharmacologic agents norepinephrine, serotonin, endotoxin, dibenzyline and acetylcholine. A new method is described for the measurement of alveolar gas volumes and capillary blood volume.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 31, 1970
- Accession Number
- AD0704696
Entities
People
- Herbert B. Hechtman
- Richard H. Egdahl
Organizations
- Boston University