THE SYNTHESIS OF NEW ANTIMALARIAL DRUGS DERIVATIVES OF BENZOTHIOPYRANS.
Abstract
The present synthetic program on benzothiopyran derivatives is based on a lead compound WR 95214. Of the compounds tested so far, fourteen compounds are active in the mice screen and five of which have produced cures at a dose level of 640 mg/kg. At present the most potent compound seems to be AT 89470 (N-N-diethyl-N'-(6-chloro-2-phenyl-4H-1-benzothiopyran-4-ylidene-1-4-pentanediamine dihydrochloride) (160 mg/kg - 14 day) but the data is not yet complete. To date only seven target compounds have been tested in the chick screen out of which five are active. Two compounds are curative in mice as well as active in the chick screen. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1970
- Accession Number
- AD0704710
Entities
People
- Avinash C. Mehta
- Raj K. Razdan
- Robert J. Bruni
Organizations
- Arthur D. Little