COMPARISON OF CHLOROQUINE/PRIMAQUINE PLUS DDS VERSUS CHLOROQUINE PLUS DDS.
Abstract
Forty-eight healthy male volunteers were divided in to two groups of 24 in a random fashion and studied over a 74 day period to determine whether the combination of Chloroquine and Dapsone produced significantly less methemoglobin than the combination of Chloroquine/Primaquine and Dapsone. During the first 12 days, all subjects received 200 mg of Dapsone daily and methemoglobin levels in excess of 5% of the total circulating hemoglobin were seen in 25% of the subjects. Following a three day wash out period, the two groups were studied in a crossover fashion to evaluate 75 mg of Dapsone plus Chloroquine/Primaquine and 75 mg of Dapsone plus Chloroquine. Methemoglobin levels in excess of 5% occurred in 50% of the subjects when they received Chloroquine and Primaquine in addition to the Dapsone. Chloroquine alone did not have a methemoglobin producing effect when given with Dapsone in this dose. In the last study period, all of the subjects received 25 mg of Dapsone daily and half of the subjects received Chloroquine/Primaquine with the other half receiving only Chloroquine. Methemoglobin in excess of 5% occurred in two individuals receiving Chloroquine and Primaquine and less significant increases in methemoglobin were observed in all subjects in that treatment group. Again, Chloroquine had no significant effect on methemoglobin levels. Throughout the study, Dapsone was administered in a single blind fashion and the Chloroquine/Primaquine and Chloroquine were administered in a double blind fashion. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1969
- Accession Number
- AD0704981
Entities
People
- D. A. Vloedman Jr
- John P. Colmore
- Kenneth Evensen
- Paul C. Desper
Organizations
- University of Oklahoma