INFLUENCE OF TEMPERATURE ON THE EFFECTS OF ENTEROTOXIN AND ENDOTOXIN IN MICE

Abstract

For optimum health, the host must control the proliferation of endogenous bacteria and neutralize harmful toxins. Staphylococcal enterotoxin B (SEB) produced by gram-positive bacteria and lipopolysaccharide endotoxin (LPS) produced by certain gram-negative bacteria can exert synergistic effects when injected into homothermic animals (mice). In both acclimatized and nonacclimatized animals, exposure to temperature extremes of 4 deg C or 35 deg C-- except in one instance--either hastens or increases death in the presence of SEB and LPS when compared to room temperature (24 deg C). This research determines experimentally that ambient temperature is a meaningful variable in the resistance or susceptibility of a mammal to certain common bacterial toxins.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1970
Accession Number
AD0705979

Entities

People

  • William G. Glenn

Organizations

  • United States Air Force School of Aerospace Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Aerospace Medicine
  • Air Force
  • Air Force Facilities
  • Animals
  • Bacteria
  • Bacterial Toxins
  • Biological Toxins
  • Endotoxins
  • Food Poisoning
  • Government Procurement
  • Governments
  • Gram-Negative Bacteria
  • Gram-Positive Bacteria
  • Laboratory Animals
  • Lethality
  • Microbiology

Readers

  • Microbial Pathology
  • Thermal Physics or Thermal Science.
  • Toxicology/Environmental Toxicology