ACTIVITY OF RAT LIVER ENZYMES RESPONSIBLE FOR GLYCOGEN METABOLISM AFTER WHOLE-BODY IRRADIATION
Abstract
The activities of liver enzymes involved in the breakdown and synthesis of glycogen have been investigated in rats exposed to 1200 rads midline kerma dose, free-in-air, of x rays or mixed gamma-neutron radiation. It was found that glycogen phosphorylase and amylo-1,6-glucosidase, both of which are involved in the breakdown of glycogen to 3glucose3 units, are greatly inhibited by both qualities of radiation. A considerable inhibition in the activity of amylo-(1,4 to 1,6)-trans-glucosidase (branching enzyme) was also observed. In contrast, it was found that the activity of UDP-glucose-glycogen transglucosylase which is responsible for the in vivo synthesis of 1,4- polysaccharides is greatly enhanced when the animal received x rays or mixed gamma-neutron radiation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1970
- Accession Number
- AD0705996
Entities
People
- C. G. Mchale
- George N. Catravas
Organizations
- Armed Forces Radiobiology Research Institute