MANIFEST PSYCHOPATHOLOGY AND URINE BIOCHEMICAL MEASURES: MULTIVARIATE ANALYSES IN MANIC-DEPRESSIVE ILLNESS
Abstract
Two hospitalized rapidly cycling manic-depressive patients underwent daily ratings by nursing staff using the Overall-Gorham Brief Psychiatric Rating Scale and daily 24-hour urine collections for assay of volume, osmolality, 17- hydroxycorticosteroids, vanillylmandelic acid, kynurenine, and indoleacetic acid. Multivariate analyses of the BPRS and biochemical data. The BPRS yields useful day-to-day measures of changes in psychopathology in manic-depressive illness and delineates specific manic and depressive symptom clusters for each patient. Regression equations for the biochemical measures were constructed to yield a 'predicted' contrast function correlating best with BPRS contrast function for each patient. Time-series plots were made with BPRS contrast function and biochemical 'predicted' contrast function together, and with BPRS and biochemical discriminant combinations together. These time-series plots generally revealed that shifts in the biochemical domain lagged several days behind shifts in the BPRS domain. It appears that the urine biochemical variables were peripheral reflections of alterations in total body metabolic pathways secondary to both specific central nervous system influences, such as ACTH release, and non-specific changes, such as level of motor activity, occurring with shifts between mania and depression. It does not appear that the urine variables measured in this study reflected any biochemical CNS changes antecedent to shifts in manifest psychopathology during the manic-depressive cycle.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 21, 1969
- Accession Number
- AD0706141
Entities
People
- John E. Overall
- Robert T. Rubin