MATERIALS FOR SUBSTANTIATION OF THE MAXIMUM PERMISSIBLE CONCENTRATION OF STREPTOMYCIN IN THE AIR OF INDUSTRIAL PREMISES,
Abstract
Studies on the substantiation of the maximum permissible concentration (MPC) of streptomycin in the air of production premises were undertaken simultaneously at a number of hygiene and clinical establishments, which made it possible to assess the obtained results from the positions of specialists in different fields. This widely used antibiotic is obtained industrially by biosynthesis from Actinomyces globisporus streptomycini. In practice the hydrochloride and sulfate salts and also the complex salt of streptomycin with calcium chloride are applied. For the experiments we used white mice and rats (230 animals) in conditions of acute and chronic experiment. Generalization and analysis of the materials presented in this article and comparison of data obtained through industrial and experimental observations made it possible to recommend that the MPC for streptomycin be set at 0.1 mg/cu.m. This concentration was confirmed by the commission for establishing MPC of harmful substances in the air of industrial premises. Besides this, sanitation measures were developed which were transmitted to the Commission of the Chemical and Pharmaceutical industry. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 30, 1970
- Accession Number
- AD0706353
Entities
People
- B. G. Shteinberg
- I. M. Trakhtenberg
- P. I. Talyantsev
- R. V. Yurina
- V. V. Paustovskaya
Organizations
- National Air and Space Intelligence Center