MUTATIONS OF APATHOGENICITY AND SMALL PLAQUES IN THE TICK-BORNE ENCEPHALITIS VIRUS INDUCED BY N-NITROSOMETHYL UREA,

Abstract

N-nitrosomethyl urea induces 100% mutations of apathogenicity in the virus of tick-borne encephalitis. The mutation from normal to small plaques are encountered 25% less frequently, and are not related to apathogenicity mutations. With respect to the degree of specificity, N-nitrosomethyl urea is superior to 1.4-bis-diasoacethyl butane, since the former evokes two types of mutation whereas 1.4-bis-diasoacethyl butane is characterized by three mutations. The nearly 100% mutation frequency brought about N-nitrosomethyl urea is achieved when the viability of the virus is decreased tenfold, and a 75% mutation frequency is obtained when the viability is decreased fivefold; this has never been observed up to now in experiments with other physical and chemical mutagens. (Author)

Document Details

Document Type
Technical Report
Publication Date
May 11, 1970
Accession Number
AD0706557

Entities

People

  • G. D. Zasukhina
  • I. A. Rapoport

Tags

DTIC Thesaurus Topics

  • Encephalitis
  • Frequency
  • Language
  • Microorganisms
  • Mutagens
  • Mutations
  • Russian Language
  • Viability
  • Viruses

Fields of Study

  • Biology

Readers

  • Mathematics or Statistics
  • Molecular Genetics
  • Virology (or Medical Virology).