THE EFFECT OF EPINEPHRINE AND THYROTROPIN ON THYROID FUNCTION IN RATS,
Abstract
There was an early decrease in gland content of radioactive iodine (I-131) after either epinephrine or thyrotropin administration in rats. The serum content after thyrotropin injection was increased (particularly the protein-bound component) due to acceleration of the release of thyroxine from the thyroid gland. In the epinephrine treated rats, however, the serum content was decreased. This is interpreted as being due to the increased peripheral demand and utilization of thyroxine. The decreased serum thyroxine level probably causes an increased pituitary release of thyrotropin and therefore produces the same effect on the thyroid gland as thyrotropin administration. A decreased content of iodine in the thyroid is not indicative of decreased functional activity and thus does not mean a decreased 'uptake.' The thyroid gland has been found to be quickly responsive to some stimuli and thus not sluggish and slow to react as has been formerly assumed. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1951
- Accession Number
- AD0706589
Entities
People
- A. L. Botkin
- H. F. Jensen
Organizations
- United States Army Medical Research Laboratory