The Chemistry and Pharmacology of Certain Compounds Affecting the Central Nervous System of Animals and Man

Abstract

EA 1476, EA 1477 and reserpine have numerous similar pharmacological effects in the dog when administered by the oral or intravenous route. EA 1476 and EA 1477 have qualitatively similar effects upon the cardiovascular system of the dog. EA 1476, EA 1477 and reserpine produce a state of tranquilization in the unanesthetized dog following intravenous administration. EA 1476 like reserpine can prolong the sleeping time of white mice induced by the intraperitoneal injection of hexobarbital. The electroencephalographic response of the unanesthetized curarized dog to 0.10 mgm./kgm. of EA 1476 administered intravenously is characterized by high voltage slow waves with some tendency to spindling. Hypothermia is an outstanding sign following intravenous administration of 1.0 mgm./kgm. of EA 1476. EA 1476 as well as reserpine depresses respiratory rate following intravenous administration to unanesthetized dogs.

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Document Details

Document Type
Technical Report
Publication Date
Nov 15, 1955
Accession Number
AD0707668

Entities

People

  • Edward F. Domino
  • Harold F. Hardman
  • Maurice H. Seevers

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Animal Structures
  • Arteries
  • Autonomic Nervous System
  • Blood
  • Blood Volume
  • Cardiac Arrhythmias
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Central Nervous System
  • Chemical Synthesis
  • Chemistry
  • Drug Abuse
  • Drug Therapy
  • Heart Rate
  • High Voltage
  • Nervous System
  • Pharmacology

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Toxicology/Environmental Toxicology