The Chemistry and Pharmacology of Certain Compounds Affecting the Central Nervous System of Animals and Men

Abstract

The extensive actions of tetrahydrocannabinol derivatives upon the cardiovascular system suggest that these agents act by inhibition of the afferent to efferent areas of the central components of the sympathetic nervous system. Behavioral changes characterized by CNS depression, ataxia, analgesia and enhanced tendon reflexes have been described. The general toxicity of the tetrahydrocannabinol derivatives is discussed as well as the effects of drugs which antagonize or potentiate their pharmacological actions. An analysis of structure activity relationship is presented for the tetrahydrocannabinol derivatives evaluated in this study.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1957
Accession Number
AD0707669

Entities

People

  • Edward F. Domino
  • Harold F. Hardman
  • Maurice H. Seevers

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Analgesia
  • Arousal (Physiology)
  • Arteries
  • Autonomic Nervous System
  • Blood
  • Brain
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Central Nervous System
  • Central Nervous System Depressants
  • Chemical Synthesis
  • Chemistry
  • Drug Abuse
  • Heart Rate
  • Hypothalamus
  • Nervous System
  • Pharmacology

Fields of Study

  • Chemistry
  • Medicine

Readers

  • Cardiovascular Physiology
  • Computer Engineering
  • Prostate Cancer Biology.