HEAT TRANSFER IN CONNECTION WITH ORGAN AND TISSUE PRESERVATION AND POSSIBLE METHODS FOR NON-DESTRUCTIVE EVALUATION OF PERIPHERAL NERVE REGENERATION.
Abstract
The complicated geometry of the renal circulation system and the nature of the tissues that surrounds it are defined by an idealized circuit for use in pressure drop and heat transfer descriptions during renal perfusion. Numerical and analytical transient heat transfer solutions for organ freezing and thawing are presented and evaluated. The results of some preliminary kidney perfusion experiments are also presented. Improved methods for the non-destructive assessment of peripheral nerve regeneration are badly needed by research investigators and neurosurgeons involved in the care of patients. An evaluation of a number of possible systems is made. Of active correlates of nerve function, the nerve action potential, recorded in vivo by means of implanted electrodes, is judged the only currently feasible variable which could yield the desired data. The application of in situ peripheral nerve electrodes to long term implantation in injured human and animal subjects is novel, and important questions must be answered before it could be used clinically. These questions, and a program for further analytical and experimental investigations, are outlined in detail. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1970
- Accession Number
- AD0707789
Entities
People
- G. L. Hody
- H. F. Poppendiek
- P. T. Meckel