EFFECTS OF ALTITUDE ON CELLULAR METABOLISM AND TERMINAL OXIDATION.
Abstract
The report presents continuation studies of the effects of altitude exposure on energy metabolism and mitochondrial activity in rats. Exposure of rats in experimental chambers at a simulated altitude of 25000 ft. resulted in a consistent elevated plasma pyruvate. The animals under these conditions developed hypophagia, weight loss, and increased hematocrits. Isolated liver and kidney mitochondria from these animals did not exhibit any alterations in cytochrone oxidase activity, respiratory control ratio, or ADP/O ratio. However state 4 respiration of kidney mitochondria was significantly and consistently decreased in altitude animals. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1970
- Accession Number
- AD0707985
Entities
People
- Armand J. Gold
- Leslie C. Costello
Organizations
- Howard University