PROSTAGLANDIN INDUCED, STRESS RELATED, PHOSPHOLIPID CHANGES IN THE RAT,
Abstract
The injection of the prostaglandin isomers (PGE1, PGF1-alpha, PGB1, and PGBx) into rats caused changes in plasma and brain phosphatidyl glycerol and related phospholipids that mimic the changes found in accelerated rats and in the plasma of physically or psychially stressed humans. The prostaglandin effects on normal rat plasma phospholipids were abolished in the hyprophysectomized rat. A similar block in phospholipid change was observed in hypophysectomized rats subjected to acceleration stress. All four prostaglandin isomers caused significant increases in plasma and brain phosphatidyl glycerol. Differences were observed in the effects on other phospholipids. Thus PGE1 decreased the total plasma phospholipid and phosphatidyl choline levels while PGF1-alpha increased both levels. PGE1 caused severe symptoms of lassitude and diarrhea in both normal and hypophysectomized rats. These effects were absent with the other prostaglandin isomers. In contrast, PGBx appeared to enhance the state of well being and lively behavior of the rat. These results, in conjunction with previous work on phospholipids in stress, implicate the prostaglandins in an adaptive response to stress which involves the mobilization of energy yielding molecular components and a gearing of metabolic events for survival. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 10, 1970
- Accession Number
- AD0708381
Entities
People
- Anna Marie Pakoskey
- B. David Polis
- Edith Polis
- H. P. Schwarz
- R. Paul Miller
Organizations
- Naval Air Warfare Center Warminster