MECHANISMS OF HEMOLYSIS.
Abstract
Following cell-wall interaction trauma, relatively few erythrocytes are immediately lysed. A much larger number are significantly damaged and undergo later destruction in vivo, or autohemolysis in vitro. The mechanism of this damage includes an increase in the oxidative metabolic cycle, and selective lipid elution. Lysolecithin activity and lipid peroxidation do not appear to be important mechanisms. Further studies of erythrocyte metabolic pathways, particularly in relationship to ATP and 2, 3-DPG, appear to be indicated to clarify their role in the progressive metabolic degeneration of the damaged erythrocyte membrane. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1970
- Accession Number
- AD0708941
Entities
People
- Eugene F. Bernstein
Organizations
- University of California, San Diego