INHIBITION OF ELECTRON AND ENERGY TRANSFER IN MITOCHONDRIA BY STEROIDS.

Abstract

Studies with highly selective inhibitors of mitochondrial respiration, such as amytal, rotenone and piericidin have largely contributed to elucidate the mechanism of electron transfer at the NADH-dehydrogenase region of the respiratory chain. These studies prompted a comparison of steroid effects with those of the above cited inhibitors. For that purpose, 19-nor-ethynyltestos-terone acetate (NEA) was chosen because, (1) with submitochondrial particles (Keilin-Hartree preparation), NEA is one of the most potent steroidal inhibitors of electron transfer (4), and (2) NEA is used in humans as a oral regulator of fertility. (Author)

Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1970
Accession Number
AD0709740

Entities

People

  • Andres O. M. Stoppani

Organizations

  • National Scientific and Technical Research Council

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Electron Transfer
  • Electrons
  • Energy
  • Energy Transfer
  • Fertility
  • Heterocyclic Compounds With 4 Or More Rings
  • Inhibition
  • Inhibitors
  • Mitochondria
  • Particles
  • Regulators
  • Respiration

Fields of Study

  • Chemistry

Readers

  • Molecular and Cellular Biochemistry

Technology Areas

  • Microelectronics