ALIEN CONSTITUENTS IN EXPERIMENTAL ATMOSPHERES
Abstract
Despite increased emphasis on inhalation toxicology in recent years it has not seemed standard practice to monitor experimental atmospheres for unexpected or unintended constituents. However, composition of atmospheres for animal exposure studies, even in simple design systems, may be quite different from expected. While little has been reported in this area in toxicologic literature, it should be recognized that physical and/or chemical interactions may occur in gas, liquid, or solid phase among pollutants at any point in the exposure system and between pollutants or products and the animals themselves in the chamber, resulting in undesirable effects on the primary study agent(s) and/or formation of new and alien gaseous or particulate constituents. This report concerns examples of the actual occurrence of just such phenomena, some details of identification and quantitation of components of a resultant alien particulate, and mention of interest and speculation which arises concerning the influence of such alien material with respect to effects on the study subjects, study design and interpretation, and the power of extrapolation from the experimental exposure to a realistic exposure situation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1969
- Accession Number
- AD0710457
Entities
People
- Kirby I. Campbell
- M. J. Knott
- M. Malanchuk
- W. L. Crider
Organizations
- United States Public Health Service