HEMODYNAMIC AND RESPIRATORY EFFECTS OF DOPAMINE ON SEPTIC SHOCK IN THE MONKEY
Abstract
This study explored the responses of the rhesus monkey in endotoxin or septic shock, to dopamine (3-hydroxytyramine) and documents metabolic and respiratory effects of maintaining the cardiac output above control levels in those animals. A decrease in cardiac output and systemic arterial pressure occurred in all animals following infusion of endotoxin. Seven were then studied during increasing infusion rates of dopamine (0.5 to 10.0 mg/min) and 5 animals received similar volumes of saline. Each increment in dopamine dose resulted in increased cardiac output. Heart rate, right atrial pressure, and systemic pressure were not altered significantly, but the systemic resistance decreased with each increment in dopamine administered. Two animals in shock after administration of live E. coli organisms had a similar response to dopamine. These parameters were unchanged in the animals that received saline, except at the highest infusion rates. In five animals the cardiac output was raised from 107 to 213 ml/kg/min by a constant infusion of 1.0 to 1.5 mg/min of dopamine. Maintenance of the cardiac output above pre-shock levels did not reverse the metabolic acidosis, hyperventilation or increased alveoloarterial oxygen gradients which occurred during the shock period prior to the dopamine infusion.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 28, 1970
- Accession Number
- AD0711018
Entities
People
- Clarence A. Guenter
- Lerner B. Hinshaw
Organizations
- University of Oklahoma