EFFECT OF NITROGEN TRIFLUORIDE ON PLASMA CONCENTRATIONS OF LACTATE, METHEMOGLOBIN, AND SELECTED ENZYMES.
Abstract
Blood samples of rats exposed to high concentrations of nitrogen trifluoride were analyzed for concentrations of serum glutamic oxalacetic transaminase (SGOT), serum isocitric dehydrogenase (ICDH), blood lactate, and methemoglobin. Inhalation of 10,000 p.p.m. NF3 for 45 minutes resulted in the conversion of 37% of the total rat hemoglobin to methemoglobin and a 6-fold increase in blood lactate at the end of exposure. Both parameters had returned to normal 4 hours later. Serum isocitric dehydrogenase did not change detectably as a result of the exposure. Serum glutamic oxalacetic transaminase was unchanged at 1 hour, but was increased 2- to 3-fold by 6 hours postexposure and remained elevated for as long as 24 hours after the exposure. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1970
- Accession Number
- AD0711044
Entities
People
- Gordon L. Coppoc
- Shelton J. Leger
Organizations
- United States Air Force School of Aerospace Medicine