ANTIGENIC AND BIOLOGICAL CLASSIFICATION OF DENGUE VIRUSES.

Abstract

Dengue viruses are the cause of two distinct diseases, dengue fever (DF), a mild and self limited illness and dengue hemorrhagic fever (DHF), a severe disease with an appreciable mortality rate. This investigation addressed itself to the hypothesis that two subpopulations of dengue viruses exist, virulent and avirulent, and that the virulence of a dengue infection is correlated with identifiable antigenic markers on the virus. In addition, an attempt was made to evaluate in sub-human primates the hypothesis that a second dengue infection is modified by host factors to result in more severe disease response. (Author)

Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1970
Accession Number
AD0711552

Entities

People

  • Henry Shotwell
  • Jordi Casals
  • Scott B. Halstead
  • Wilbur G. Downs

Organizations

  • Yale University

Tags

DTIC Thesaurus Topics

  • Bacterial Infections And Mycoses
  • Classification
  • Dengue
  • Diseases And Disorders
  • Infection
  • Microorganisms
  • Virulence
  • Viruses
  • Wound Infections

Fields of Study

  • Medicine

Readers

  • Virology (or Medical Virology).