STRUCTURE-FUNCTION ANALYSIS OF ANTIMALARIAL COMPOUNDS.

Abstract

The multiple parameter regression analysis approach pioneered by Prof. Hansch was applied to determine structure-activity relationships of quinolinaminocarbinols and the phenanthrene aminocarbinols as antimalarial agents. Data for avian antimalarial activity of quinolines have been compared with data obtained in mice for related compounds. Mouse data for phenanthrenes have led to mathematical expressions which have permitted predictions for novel phenanthrenes to be made. A study of phototoxicity data (in mice) of quinoline aminocarbinols did not uncover any useful differences between antimalarial and phototoxicity structure-function relationships. The utility of a three-dimensional graphing technique to exhibit structure-activity relationships was demonstrated in certain situations. (Author)

Document Details

Document Type
Technical Report
Publication Date
Apr 15, 1970
Accession Number
AD0711975

Entities

People

  • Paul N. Craig

Tags

DTIC Thesaurus Topics

  • Antimalarials
  • Chemical Compounds
  • Cyclic Compounds
  • Data Science
  • Information Science
  • Mathematics
  • Organic Compounds
  • Phenanthrenes
  • Quinolines
  • Regression Analysis
  • Three Dimensional

Fields of Study

  • Chemistry

Readers

  • Computational Modeling and Simulation
  • Parasitology and Pharmacology of Malaria.