STUDIES ON THE HYDROLYSIS AND ABSORPTION OF FOLIC ACID POLYGLUTAMATES IN TROPICAL SPRUE.

Abstract

Certain conjugated bile salts have been shown to be inhibitors of folic polyglutamate hydrolase. This enzyme has been shown to be present in bile. The folic acid compounds of human bile have been studied. Portal blood has been shown to be free of folic polyglutamates proving prior hydrolysis. The enzyme has been shown to be present in hepatic lysosomes. Further studies in tropical sprue have shown malabsorption of folic polyglutamate. Enzyme levels in biopsies have been normal. The enzyme has been localized in intestinal mucosa to lysosomes and supernatant fractions. Studies are anticipated in the Dominican Republic in cooperation with the Dominican Army. (Author)

Document Details

Document Type
Technical Report
Publication Date
May 01, 1970
Accession Number
AD0712398

Entities

People

  • Leslie H. Bernstein
  • Sidney Gutstein
  • Simeon Pollack
  • Simon Weiner

Organizations

  • Albert Einstein College of Medicine

Tags

DTIC Thesaurus Topics

  • Absorption
  • Biological Pigments
  • Cooperation
  • Dominican Republic
  • Enzymes
  • Hydrolases
  • Hydrolysis
  • Inhibitors
  • Lysosomes
  • Republic
  • Tropical Sprue

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biochemistry
  • Toxicology/Environmental Toxicology