EVALUATION OF HUMAN PLASMA AFTER PROLONGED STORAGE IN PLASTIC CONTAINERS.
Abstract
The plasma was stored for 2-5 years at room temperature, at 3-6C, or at -18C. Samples from the stored plasma were tested for bacterial contamination, chemical and protein content. None of the samples showed bacterial growth. None of the samples had plasma hemoglobin values over 25 mg/100 ml, although the pooled unit group had a slightly higher average than the single unit group. Electrolyte values were within the range found in whole blood after 21 days' storage. Total protein was within the normal range, although protein electrophoresis detected minor differences in distribution. A decrease in fibrinogen with age was observed and confirmed by specific immunoelectrophoresis. Minor increase in alpha 2 and beta globulin on electrophoresis was felt to reflect contamination from residual fibrinogen fragments migrating in the same area. The deterioration of fibrinogen appeared to be aggravated by storage at room temperature. Thus, the use of frozen plasma would appear to be more effective, although the overall changes detected would suggest that plasma can still remain usable after 4-5 years of storage. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 07, 1970
- Accession Number
- AD0712965
Entities
People
- Ben F. Castaneda
- Charles E. Shields
Organizations
- United States Army Medical Research Laboratory