DECREASED DIURESIS IN RESPONSE TO A THIAZIDE DIURETIC AT A SIMULATED ALTITUDE.
Abstract
The effect of hydrochlorothiazide on the diuretic response of rats at 12,000 ft. was examined. After administration of a saline load, with and without drug, urine was collected over a 5-hr. period at both altitude and ground level. Total volume, urinary Na(+) and K(+), and pH were determined. The most pronounced effect of the altitude-drug interaction was decrease in the expected urine volume while the increased Na(+) output did not change from the observed with the drug at ground level. The results are discussed in relation to the possible basis for the observed phenomenon. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1970
- Accession Number
- AD0713069
Entities
People
- James H. Merritt
- Thomas S. Sulkowski
Organizations
- United States Air Force School of Aerospace Medicine