A HISTOCHEMICAL STUDY OF LIVER ENZYMES INVOLVED IN GLYCOGEN METABOLISM IN THE X-IRRADIATED RAT
Abstract
The liver enzymes responsible for the breakdown and synthesis of glycogen from glucose have been investigated cytochemically in rats exposed to 1200 rads of x rays. It was found that significant changes occur in their activities and that amylophosphorylase and amylo-1,6-glucosidase, both of which are responsible for the conversion of glycogen to glucose, are markedly inhibited by radiation. A significant inhibition of the activity of 1,4 to 1,6 transglucosidase (branching enzyme) was also observed. In contrast, the activity of UDPG-glycogen transglucosylase, which is responsible for the in vivo synthesis of 1,4-polysaccharides, was found to be enhanced.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1970
- Accession Number
- AD0713087
Entities
People
- C. G. Mchale
- George N. Catravas
Organizations
- Armed Forces Radiobiology Research Institute