Morphological Changes in Guinea Pigs Following Enteral Immunization With Plague EV Vaccine,

Abstract

The authors studied the structural changes in the organism of guinea pigs enterally immunized with plague EV vaccine in a dose of 250 million and 20 billion microbial cells. Immunomorphological changes in the form of proliferation of lymphoidal and reticular tissues with formation of epithelioido-cellular granulomas, macrophagic reaction and hyperplasia of pyroninophilic elements developed in the mesenteric lymph nodes. Changes in the spleen and remote lymph nodes were insignificant. Productive mesenterial lymphadenitis with granulomatosis resolved by the 18th day from the time of immunization of guinea pigs, even when massive doses were used. (Author)

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1970
Accession Number
AD0713983

Entities

People

  • A. I. Khoklova
  • G. F. Rozhkova
  • S. I. Zaplatina
  • V. I. Ternovoi

Organizations

  • United States Army Foreign Science and Technology Center

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Animals
  • Biological Sciences
  • Cells
  • Eukaryotes
  • Hyperplasia
  • Immune System Phenomena
  • Immunization
  • Immunomodulation
  • Lymph Nodes
  • Lymphatic Diseases
  • Lymphatic System
  • Rodents

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech