Studies on Drug-Induced Immunological Tolerance.
Abstract
The investigation involved the preparation of chemicals suitable for immunological screening and the immunological evaluation of these compounds. Thirteen cyclophosphamide analogs were synthesized. Following a preliminary determination of their acute toxicity, these compounds were evaluated first in sheep erythrocyte (SRBC) tolerance tests, and then in skin allograft tolerance tests. Two compounds, namely phosphoramidic mustard (NSC-69,945) and cytoxyl alcohol (NSC-52,695) were found to be especially active in inducing specific tolerance in mice in the SRBC test. Of these two compounds only one, namely cytoxyl alcohol, showed also a significant activity for the prolongation of the life of skin allografts in mice. The interesting phenomenon of the breakdown of immunological tolerance by a single injection of a suitable compound was discovered during these studies. This phenomenon, which might have important implications for cancer and viral chemotherapy, has been brought about by a mixture of phosphoramidic mustard and cytoxylamine and, to a lesser extent, by compounds NSC-72,505 and NSC-72,509. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 30, 1970
- Accession Number
- AD0714158
Entities
People
- Anthony P. Monaco
- Harvey George
- Nicolas A. Starkovsky
- Orrie M. Friedman
- Robert E. Schwartz