Intestinal Digestion and Absorption of Sugars and Peptides.
Abstract
The sucrase-isomaltase complex, as prepared from the small intestine by papain solubilisation and Sephadex chromatography, has a ml. wt. of approximately 190 000 and is composed of 6 subunits. Its amino acid composition, its content in SH and SS groups have been determined. The sucrase-isomaltase complex binds glucose reversibly. This binding requires Na(+) and is inhibited by a number of sugars and sugars analogues which are absorbed by the same transport system as glucose. Phlorizin is hydrolyzed by an enzyme bound to the brush borders. There is a close correlation between 'phlorizin hydrolase' activity and the extent of phlorizin inhibition of intestinal sugar transport. Preliminary evidence indicates that more than one carrier may be involved in the transport of 6-deoxy-D-glucose. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 14, 1970
- Accession Number
- AD0714682
Entities
People
- Giorgio Semenza
Organizations
- University of Milan