Interaction of Chlorpromazine and Tissue Binding Sites: Preliminary Studies.

Abstract

Minced tissue from various body components of rat were subjected to equilibrium dialysis after incubation with chlorpromazine (CPZ). Radioactive CPZ (35S-labeled) was used as a tracer. Tissue binding at low concentrations (0.8 to 3.4 micrograms/ml.) and higher concentrations (0.2 to 4 mg/ml.) demonstrated binding averages. At the higher incubation concentrations, a decrease in slope estimates indicated probable secondary binding sites. (Author)

Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1970
Accession Number
AD0714851

Entities

People

  • Albert T. Bernardini

Organizations

  • United States Air Force School of Aerospace Medicine

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Chemical Compounds
  • Chemical Reaction Properties
  • Chlorpromazine
  • Cyclic Compounds
  • Dialysis
  • Heterocyclic Compounds
  • Incubation
  • Organic Compounds
  • Phenothiazines

Readers

  • Molecular and Cellular Biochemistry
  • Toxicology/Environmental Toxicology