Neurotropic Effects in Relation to Chemical Structure.
Abstract
Further attempts were made to separate the endo and exo isomers of 1, 4-dihydro-9, 10-dimethyl-1,4-ethanonaphthalene-2-3-dicarboxylic anhydride. The completion of the synthesis of substituted 11-amino-methyl-9,10-ethano-9,10-dihydroanthracene is also reported. The synthesis of two new series of bicyclic compounds derived from 11-(beta-aminoethyl)-9,10-ethano-9,10-dihydroanthracene and 11-(aminoacetoxy)-9,10-ethano-9,10-dihydroanthracenes are listed. Acute toxicities of substituted 11-aminomethyl-9,10-ethano-9, 10-dihydroanthracenes,11-(beta-aminoethyl)-9,10-etnano-9,10-dihydroanthracenes and aminoesters and aminoamides of 9,10-ethano-9,10-dihyroanthracene-11-carboxylic acides were measured. The antispasmodic activities of substituted 4,9-0-benzobenz(f)isoindolines and 11-aminomethyl-9,10-ethano-9,10-dihydroanthracenes were also determined. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 28, 1966
- Accession Number
- AD0715388
Entities
People
- Hugh B. Donahoe
- William J. Hufker
Organizations
- Saint Louis University